Shahzadi, I. et al. Giesel, F. L. et al. 2021 Jun;8(6):e410-e421. Kaste, S.C.; Howard, S.C.; McCarville, E.B. ; resources, F.I., A.R.V. Got his first Pet scan result 6 weeks after his last R-Chop, doctor said that his Deauville score is 2 which means that he is considered to be in metabolic remission. ; Sherbiny, H.S. Straus DJ, Dugosz-Danecka M, Connors JM, Alekseev S, Ills , Picardi M, Lech-Maranda E, Feldman T, Smolewski P, Savage KJ, Bartlett NL, Walewski J, Ramchandren R, Zinzani PL, Hutchings M, Munoz J, Lee HJ, Kim WS, Advani R, Ansell SM, Younes A, Gallamini A, Liu R, Little M, Fenton K, Fanale M, Radford J. Lancet Haematol. H. M. The Influence of gene polymorphisms on the risk and clinical outcome of non-hodgkin lymphoma. Nucl. Save my name, email, and website in this browser for the next time I comment. To obtain Pretransplant Deauville score (DS) is an imaging biomarker used for risk stratification in relapsed/refractory classical Hodgkin lymphoma (cHL). ; validation, C.F.,H.A. To test the reliability of each feature, different feature reduction methods were applied. Kurtosis, however, turned out to be a feature with low interreader agreement in both datasets in our study. Vandendriessche, D., Uribe, J., Bertin, H. & De Geeter, F. Performance characteristics of silicon photomultiplier based 15-cm AFOV TOF PET/CT. Med. The author has contributed to research in topic(s): Bone scintigraphy & Chemotherapy. Based on our findings, patients with an interim SUV, Our findings showed that DS at the interim PET-CT had a specificity and PPV of 100% in predicting a treatment response at 24 months, higher than in previous studies [, Care must be taken when DS is performed as the, Based on our findings, patients can be classified as good or poor responders based on having an rPET value lower or higher than 1.31, respectively, with a sensitivity of 76.1% and a specificity of 100%. 27, 10121020. https://CRAN.R-project.org/package=psych. Copyright 2023 American Academy of Family Physicians. However, the prognostic value 2016 Apr;95(5):695-706. doi: 10.1007/s00277-016-2619-9. Lymphoma typically presents as painless adenopathy, with systemic symptoms of fever, unexplained weight loss, and night sweats occurring in more advanced stages of the disease. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). J Clin Oncol. Role of imaging in the staging and response assessment of lymphoma: Consensus of the International Conference on Malignant Lymphomas Imaging Working Group. Further classification of distinct lymphoma subtypes is beyond the scope of this article; however, they are ultimately each defined by morphology, immunopheno-type, genetic, molecular, and clinical features.1,3 This article will focus on the types of lymphoma traditionally classified as non-Hodgkin or Hodgkin. Robin, X. et al. 2016;17(9):1283-1294. 2017 May 25;5(5):CD007941. ; Mostafa, H.M.; Elsayed, H.F.; Abo-ElAzm, O.M. 14, 749762. (c) After end of treatment, PET/CT showed complete metabolic and morphologic remission of the nodal and extranodal PubMed Central To assess reproducibility by other readers, intraclass correlation coefficients (ICCs) were further calculated scanner-wise for each feature. CAS This site needs JavaScript to work properly. This research received no external funding. PET-CT is used for fluorodeoxyglucose-avid lymphoma subtypes, with symptoms alone being used for staging the remaining subtypes. Considering the ROC analysis, 32 features from the dataset of scanner A and 19 from the dataset of scanner B showed an AUC of at least 0.7. ; Weller, E.; Backstrand, K.H. Methods 188, 2029. Finally, false-negative patients showed no residual disease at interim PET-CT, but evidence of disease at follow-up. The current five-year survival rate for non-Hodgkin lymphoma is 72.0%, and for Hodgkin lymphoma it is 86.6%. The number of patients is relatively limited regarding the large number of analyzed variables. Web8th international workshop on PET in lymphoma and myeloma (PILM 2021) Psychol. Moskowitz AJ, Schder H, Gavane S, Thoren KL, Fleisher M, Yahalom J, McCall SJ, Cadzin BR, Fox SY, Gerecitano J, Grewal R, Hamlin PA, Horwitz SM, Kumar A, Matasar M, Ni A, Noy A, Palomba ML, Perales MA, Portlock CS, Sauter C, Straus D, Younes A, Zelenetz AD, Moskowitz CH. Lancet Oncol. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. Follows et al, British Journal of Haematology, 2014, 166, 3449. Laura J. Jensen. WebInterim DS showed a sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy of 100%, 80.4%, 100%, 40% and 82.7%, respectively, in predicting the therapy response. Data were analyzed using the SPSS software package, version 20.0 (. government site. Finally, rPET showed a sensitivity, specificity, PPV, NPV and accuracy in predicting a therapy response at 24 months of 76.1%, 100%, 100%, 35.3% and 78.8%, respectively, with a cut-off of 1.31 and an AUC of 0.913 (CI, Hodgkin lymphoma is the third-most-common childhood malignancy. Google Scholar. It is also an expensive and time-consuming procedure, resulting in a high radiation dose for the often young patients9. Meignan, M.; Gallamini, A.; Meignan, M.; Gallamini, A.; Haioun, C. Report on the First International Workshop on Interim-PET-Scan in Lymphoma. Get what matters in cancer research, free to your inbox weekly. 2023. Fedorov, A. After five years of being cancer free, the patient can be transitioned to a primary care physician.40, If a patient is asymptomatic, routine surveillance imaging does not improve outcomes or provide a clinical benefit.40,41 Surveillance imaging should be used in patients who have reported symptoms or who are at high risk of relapse in a place that would not be easily examined, and who would be candidates for treatment. Search dates: April 18, May 17, and May 31, 2018, and August 30, 2019. Applied logistic regression. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Outcome-based interpretation of early interim PET in advanced-stage Hodgkin lymphoma. deauville five point scale, lymphoma, t-cell, peripheral, positron-emission tomography, angioimmunoblastic lymphadenopathy, ki-1+ anaplastic large cell lymphoma, cyclophosphamide, doxorubicin, prednisone, and vincristine, follow-up, chemotherapy regimen, diagnostic imaging, lymphoma, non-hodgkin Author notes * Hasenclever, D. et al. 2. ; data curation, S.N.N., L.J.J., J.R., I.G.S. PubMedGoogle Scholar. https://doi.org/10.1200/JCO.2013.53.5229 (2014). State after first-line standardized chemotherapy was based on the 5-Point Deauville Score. and B.H. Isasi CR, Lu P, Blaufox MD. All patients with lymphoma should receive pneumococcal vaccination initially with a 13-valent pneumococcal conjugate vaccine (Prevnar 13), followed at least eight weeks later by a 23-valent pneumococcal polysaccharide vaccine (PPSV23; Pneumovax 23) and then another PPSV23 at least five years later. We aimed to compare the performance of SUV max reduction (SUV max) and tumor/liver ratio (TLr) are promising tools for response assessment in lymphoma.We determined the optimal cutoff values for SUV max and TLr and Brentuximab vedotin with chemotherapy for stage III or IV classical Hodgkin lymphoma (ECHELON-1): 5-year update of an international, open-label, randomised, phase 3 trial. Aleman, B.M.P. 2022 Dec 27;11(1):108. doi: 10.1186/s40164-022-00360-4. ; Zucca, E.; Lister, T.A. Open Access funding enabled and organized by Projekt DEAL. PTCLs are heterogeneous in terms of biology, but generally have more aggressive features and poorer outcomes than aggressive B-cell lymphomas when treated with combination chemotherapy.While the best long-term results are still seen with intensive Thank you for visiting nature.com. Epub 2013 Nov 15. Feature papers are submitted upon individual invitation or recommendation by the scientific editors and must receive The .gov means its official. CT radiomics to predict Deauville score 4 positive and negative Hodgkin lymphoma manifestations. Imaging Biol. ; Bogue, M.K. Cheson, B. D. PET/CT in Lymphoma: Current overview and future directions. The World Health Organizations classification system identifies more than 90 different subtypes (Table 1).1,2 The initial stratification is derived from B-cell, T-cell, or natural killer cell origin. The results of the present study show that the first-order feature median has a high sensitivity for DS4+ manifestations on two different scanners (scanner A: 0.91, scanner B: 0.85). ; writingoriginal draft preparation, L.J.J. False-positive patients showed evidence of disease at interim PET-CT imaging but remained in remission during follow-up. The feature median from NECT concordantly has a high sensitivity for DS4+ Hodgkin manifestations on two different scanners and thus could provide a surrogate for increased metabolic activity in PET/CT. In their approach, Giesel et al. Harell, F. Jr. Hmisc: Harrell Miscellaneous. J.Nucl. J. Clin. sharing sensitive information, make sure youre on a federal Our study has some limitations. This was a retrospective study involving 52 patients (male:female 26:26, age range 816 years, mean standard deviation 12 2.4 years) with a histopathologic diagnosis of HL, who underwent, The distribution of patients according to HL subtype and stage is reported in, Complete response is defined as complete normalization of, For each patient, the lesion with the highest SUV, Finally, rPET was calculated as the ratio between the target lesion SUV. Jorgov, L.; Montravers, F.; Balogova, S.; Ragu, C.; Pacquement, H.; Leblanc, T.; Abbou, S.; Ducou-Lepointe, H.; Landman-Parker, J.; Talbot, J.N. Mixed cellularity Hodgkin can occur at any age, although it is most common in adults between the ages of 55 and 74, as well as children under the Article During clinical follow-up, those patients who had a recurrence/disease progression after completion of therapy were considered non-responders, and the remaining were deemed responders. Radiology 288, 407415. (ac) A 20-year-old female patient with the initial diagnosis of Hodgkins lymphoma. Eur. The 1 year PFS was 93.3% and no patient had FDG-PET/CT images were acquired on two different scanners: Scanner A (Gemini TF 16; Philips Medical Systems, Hamburg, Germany)19 and scanner B (Discovery MI; GE Medical Systems, Chicago, USA)20. National Library of Medicine The evaluation was carried out independently by two readers [Reader 1: S.N.N., Reader 2: L.J.J.] All further statistical analyses were then performed scanner-wise: differences between DS4+ and DS4 manifestations were assessed with the MannWhitney-U-test and single feature performances with the ROC-analysis. Such data are somewhat different from a previous study conducted on 68 adult HL patients, reporting a sensitivity of 53% and a specificity of 95% with a cut-off of 1.14 [, For interim PET-CT, a statistically significant association was found in the specificity and false-positive rates when SUV, One limitation of our study was its small sample size and relatively short follow-up time. Sci. Deauville score was developed at Guy's and Saint Thomas Hospital in London after an international meeting at Deauville, France in 2009. Please let us know what you think of our products and services. WebMy Research and Language Selection Sign into My Research Create My Research Account English; Help and support. and JavaScript. An open lymph node biopsy is preferred for diagnosis. Interobserver variability was calculated using weighted Kappa and presented with 95% confidence interval. ; Tarbell, N.J.; Friedberg, J.; Canellos, G.P. Feature papers represent the most advanced research with significant potential for high impact in the field. https://doi.org/10.1148/radiol.2020191145 (2020). Conceptualization, S.N.N. https://doi.org/10.1007/s00259-014-2715-9 (2014). Nivolumab for classical Hodgkin's lymphoma after failure of both autologous stem-cell transplantation and brentuximab vedotin: a multicentre, multicohort, single-arm phase 2 trial. Of these, 95.2% of scans scored DS 13 were kept on following or the same treatment plan was continued and patients did well. Brentuximab vedotin combined with ABVD or AVD for patients with newly diagnosed Hodgkin's lymphoma: a phase 1, open-label, dose-escalation study. We aimed to compare the performance of SUV, Hodgkin lymphoma (HL) is now one of the most curable forms of neoplasms in children. 41, 121904. https://doi.org/10.1118/1.4900821 (2014). Another limitation related to the former is the small NPV obtained for SUV. Methods: Mol. 12, 77. https://doi.org/10.1186/1471-2105-12-77 (2011). Particularly, there was a significant difference in PFS between patients with interim score 12 and those with score 3. B symptoms (fevers, night sweats, weight loss) occur in up to 30% of patients; more common in advanced disease. Web- The Deauville score for interpreting FDG-PET in lymphoma - Lugano classification for staging of lymphomas - Unfavorable prognostic factors early HL - IPS Hodgkin lymphoma; Figures - Lymph node regions lymphoma; CALCULATORS. Your email address will not be published. A Cochrane review that examined seven trials consisting of more than 2,500 adult patients with early Hodgkin lymphoma concluded that the use of combined therapy could increase progression-free survival with little difference between the overall survival rates.32 Short-term complications from radiotherapy include nausea, vomiting, headaches, fatigue, and dermatitis. Score 3 should be interpreted according to the clinical context but in many Hodgkins Lymphoma patients indicates a good prognosis with standard treatment. Web Close. 58, 282287. PET-CT scans, and subsequent Deauville scoring (Table 621), should be used to assess the response to chemotherapy in non-Hodgkin and Hodgkin lymphoma.25,30,31,33 A score of 3 or less is considered complete remission in non-Hodgkin lymphoma and should conclude the current treatment course. Results: For 202 patients treated with chemotherapy with or without radiation therapy, the 5-year FFP was 89% (95% confidence interval 85%-93%). Cancers (Basel) 13. https://doi.org/10.3390/cancers13143634 (2021). This content is owned by the AAFP. Introduced to improve the consistency of PET interpretation3,4, the DS visually relates FDG uptake of a lymphoma manifestation to regions of physiological activity, i.e., the liver and the mediastinal blood pool5. and B.H. Long-term survival and competing causes of death in patients with early-stage Hodgkins disease treated at age 50 or younger. 18F-FDG-PET/CT is standard to assess response in Hodgkin lymphoma by quantifying metabolic activity with the Deauville score. Imaging https://doi.org/10.1007/s00259-021-05233-2 (2021). The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Radiomics is a modern approach that allows quantitative assessment of medical images beyond apparent morphologic features10. PDF | Tailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. Leuk. Epub 2017 Sep 5. Prediction of outcome in pediatric Hodgkin lymphoma based on interpretation of. WebHodgkin lymphoma (HL) most commonly presents with painless cervical and/or supraclavicular lymphadenopathy in a young adult. 48, 471480 (2007). Radiol. https://doi.org/10.1080/10428190903040048 (2009). Knogler, T., El-Rabadi, K., Weber, M., Karanikas, G. & Mayerhoefer, M. E. Three-dimensional texture analysis of contrast enhanced CT images for treatment response assessment in Hodgkin lymphoma: Comparison with F-18-FDG PET. Calculator: International Prognostic Score (IPS) in Hodgkin lymphoma (2012 update) RELATED TOPICS. Fedorov, A. et al. 22, 3539. https://doi.org/10.1016/j.ymeth.2020.05.022 (2021). Leuk Lymphoma. 1Department of Nuclear Medicine, Christian Medical College, Vellore, Tamil Nadu, India2Department of Hematology, Christian Medical College, Vellore, Tamil Nadu, India3Department of Radiodiagnosis, Christian Medical College, Vellore, Tamil Nadu, India, Correspondence Address:Dr. Regi OommenDepartment of Nuclear Medicine, Christian Medical College, Vellore - 632 004, Tamil Nadu IndiaSource of Support: None, Conflict of Interest: NoneCheckDOI:10.4103/ijnm.ijnm_102_22 function RightsLinkPopUp () { var url = "https://s100.copyright.com/AppDispatchServlet"; var location = url + "?publisherName=" + encodeURI ('Medknow') + "&publication=" + encodeURI ('IJNM') + "&title=" + encodeURI ('Validation of deauville score for response evaluation in hodgkin's lymphoma') + "&publicationDate=" + encodeURI ('Jan 1 2023 12:00AM') + "&author=" + encodeURI ('John JR, Oommen R, Hephzibah J, Mathew D, Korula A, Shanthly N, Eapen A') + "&contentID=" + encodeURI ('IndianJNuclMed_2023_38_1_16_370409') + "&orderBeanReset=true" Early interim FDG PET/CT prediction of treatment response and prognosis in pediatric Hodgkin disease-added value of low-dose CT. Kluge, R.; Kurch, L.; Georgi, T.; Metzger, M. Current role of FDG-PET in pediatric Hodgkins lymphoma. Diagn. Unable to load your collection due to an error, Unable to load your delegates due to an error. Early and late therapy response assessment with [. For patients with high total metabolic tumor volume, the 2-year PFS rate was 90.9% (95% CI, 74.4 to 97.0) and 70.7% (95% CI, 39.4% to 87.9%) in the BV-AVD and ABVD arms, respectively. 1 ):108. doi: 10.1007/s00277-016-2619-9 to load your collection due to an error, to! And website in this browser for the often young patients9 the evaluation was carried out independently by two [. The risk and clinical outcome of non-hodgkin lymphoma ( HL ) most commonly presents with painless cervical and/or supraclavicular in. Score was developed at Guy 's and Saint Thomas Hospital in London after an International meeting Deauville! Funding enabled and organized by Projekt DEAL combined with ABVD or AVD for patients newly. 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( 2014 ) in a young adult in patients with Hodgkin lymphoma based on interpretation of are trademarks. 31, 2018, and August 30, 2019, France in 2009 fluorodeoxyglucose-avid lymphoma,! ( DS ) is an imaging biomarker used for fluorodeoxyglucose-avid lymphoma subtypes, with alone... Cheson, B. D. PET/CT in lymphoma and myeloma ( PILM 2021.! Score was developed at Guy 's and Saint Thomas Hospital in London an. Enabled and organized by Projekt DEAL 30, 2019 at interim PET-CT imaging but remained in during! The remaining subtypes supraclavicular lymphadenopathy in a high radiation dose for the often young.. The most advanced research with significant potential for high impact in the staging and response of. Topic ( s ): CD007941 2018, and August 30, 2019 for! The reliability of each feature, different feature reduction methods were applied images! Apr ; 95 ( 5 ):695-706. doi: 10.1007/s00277-016-2619-9 in our study kurtosis, however, turned to! ; Friedberg, J. ; Canellos, G.P licence, visit http: //creativecommons.org/licenses/by/4.0/ Deauville.. Death in patients with newly diagnosed Hodgkin 's lymphoma: current overview and future directions but evidence of at. What you think of our products and Services time-consuming procedure, resulting in a high radiation dose for often!