The Forgotten - Your Soul is now unchained and free to move. Unlock Condition: Collect 3 Astrology related items (Zodiac items, fortune-teller related items, etc.). ?, Satan and The Lamb as Tainted Lazarus, All new chests become locked Golden chests, UNLOCK: Unlock this trinket by defeating Isaac, ?? Will take red hearts first before any other, Eve starts with this item after donating 439 coins to the Greed Donation Machine, UNLOCK: Unlock this item by beating Satan with Eve, Item Pool: Item Room, Curse Room, Demon Beggar, * devil pool, devil room pool, devil deal, the lost item pool, starting, silver, grey, gray, Upon use, this item refreshes the current floor with brand new rooms, monsters and items, as if you had entered a new floor, UNLOCK: Unlock this item by beating Satan with Blue Baby, Item Pool: Item Room, Secret Room, Devil Room, Demon Beggar, * secret room pool, item room, treasure room, item room pool, pill, tablet, drug, white, . Taking this item DOES count as a devil deal, preventing future angel rooms. UNLOCK: Unlock this item by defeating Lil Horn 20 times, When picked up, gives Isaac a random familiar which has a random sprite and tear effect, The familiar will be fully randomized again upon entering the next floor, The appearance is chosen from a random co-op baby sprite, Added as part of the Afterbirth+ Booster Pack #1 and based on the Steam Workshop mod created by Ashkait and Scayze, A familiar that will transform into another random familiar every 10 seconds, copying their behaviour and effect, Can be any other familiar, including (but not limited to) Lil Brimstone, Bob's Brain, BBF, Meatboy, Rotten Baby, Familiars appear as a white Delirium version of the original, This item gives you 1 bar of charge on your active item for every 15 enemies you kill, Added as part of the Afterbirth+ Booster Pack #2 and based on the Steam Workshop mod created by Ashkait and Scayze, UNLOCK: Unlock this item by picking up any 3 of these items in a single run: 9 Volt, The Battery, Car Battery, AAA Battery, Watch Battery, When used, the coupon causes one random item in the shop to become free, While held, guarantees a random item or pickup from the shop to be half price, The effect of this item also works in Devil Rooms, allowing you to take one random item for free, Added as part of the Afterbirth+ Booster Pack #2 and based on the Steam Workshop mod created by Plumbo, *, paper, square, green, pink, white, barcode, letter, postcard, An active that causes all enemy tears to be held in place and then thrown back away from Isaac for a period of 3 seconds, The aura from this item will repel nearby enemies, Added as part of the Afterbirth+ Booster Pack #2, When used, the box will pick up a maximum of 6 items. Kills poop bosses when used - Dingle, Dangle and Brownie, * item room, treasure room, item room pool, silver spoon handle, grey, gray, white, toilet. Using Sumptorium as her will then cause all Clots to be consumed and return your hearts back to you. (Blue baby), *, dead, blue, face, fates reward, fate reward, A familiar chest that follows Isaac and has a 25% chance to drop a pickup after clearing a room, Possible drops include hearts, coins, bombs, key, pills, card, runes, batteries, trinket, UNLOCK: Unlock this item by beating Greed Mode with Isaac, Item Pool: Item Room, Greed Mode Item Room, Beggar, An orbital angel which does 7 contact damage per tick and blocks shots, The angel will attract bullets towards it and block them, Sworn Protector will drop an eternal heart if it blocks 10 shots in one room. If the player has all mapping effects, it grants the "I can see forever!" Replacing all 12 containers with broken hearts will kill you instantly. ?, Satan and The Lamb as Tainted Magdalene, The first time you pick this trinket up, the heart container will be filled. In The Binding of Isaac: Repentance, there are two routes to unlock Jacob and Esau. UNLOCK: Unlock this item by defeating Ultra Greed as Apollyon, At the start of each new hostile room, you have a 20% chance to gain a random charmed familiar which will fight for you, The charmed enemy has its own health bar and will die if it takes enough damage, Charmed enemies persist between each room and floor for as long as they stay alive, Allows you to have more than one charmed familiar at a time if you can keep them alive, * pokemon, phone, black, green, blue, gps, Every time one of your tears hits an enemy, it has a chance to start bleeding, which will cause it to take damage every 5 seconds, The bleed damage dealt by BackStabber is based on how quickly an enemy is moving (faster enemies take more damage), Damaging enemies from behind gives the bleed effect a 100% chance to apply, While an enemy bleeds, they leave behind creep that damages other enemies, The tear that inflicts the bleed effect also deals double damage, *, knife, dagger, red, heart, silver, knife, When used, Sharp Straw will deal damage to all enemies in the room, The damage dealt is equal to Isaac's current tear damage plus 10% of the enemy's max health, Every time this item deals damage, it has a 15% chance to drop 1/2 red hearts, REPENTANCE - Sharp Straw is now only able to generate half red hearts (previously, it generated half soul hearts if the player had no heart containers), A razor blade orbital that deals contact damage and applies the bleeding status effect to enemies and bosses, which will cause them to take damage every 5 seconds, The contact damage dealt by Mom's Razor is based on how quickly an enemy is moving (faster enemies take more damage), Its speed is not affected by the Guardian Angel item, An eye orbital that shoots tears that deal 3.5 damage and deals 2 contact damage per tick to enemies, The damage dealt by this orbital does not scale with damage upgrades, REPENTANCE - Bloodshot Eye now blocks enemy shots, has increased shot speed and rate of fire, and now only shoots when lined up with enemies, When used, spawns a charmed random white delirium version of a boss, that will fight for you and kill other enemies for the rest of the current room, Possible bosses spawned include most bosses in the game, Some bosses' effects can harm Isaac. Function: Spending money gives out random stat boosts, Unlock Condition: Defeat Mother as Keeper. the Secret Room or the Shop, Every time the portal sucks up an item, it spawns a blue attack fly for you, Once every room has been explored, the portal does nothing, Cannot take you to rooms that aren't a part of the floor structure e.g. Bethany - Activating an item using soul charges is sometimes free, Jacob & Esau - The character who picks up Birthright gains copies of three of the other character's passive items, UNLOCK: Unlock this item by defeating ??? Maggy - +1 HP up. With the nerf to the Devil Room pool quality overall, this item is the strongest new addition to that pool. Health down effects still only remove 1 heart, Eve - Whore of Babylon and Dead Bird effects are always active, Samson - Bloody Lust can gain 4 more damage boosts, for a new max total of +14 Damage, Azazel - His beam becomes much wider, no effect on damage. ?, Satan and The Lamb as Tainted Samson, When taking damage you have a chance to explode and deal 185 damage to all enemies around you (Same damage as a Mr. Mega bomb), UNLOCK: Unlock this trinket by defeating Mother as Tainted Samson, Familiars follow Isaac's exact movements, (similar to how Jacob & Esau work) instead of following loosely like they usually do, Holding the drop button (Ctrl on Steam version) causes them to stop moving, Doesn't affect some familiars with specific movement patterns, e.g. Killing a petrified enemy will freeze it. item room pool, red, boom, tnt, * item room, treasure room, item room pool, wooden, cross, brown, Isaac can now hold two trinkets at the same time, Drops a random trinket on the floor when picked up, Allows you to pick up more trinkets while also holding The Tick, * shop room pool, shop item pool, purple, pink, bag, All of Isaac's bombs now leave a poison effect on any enemies within the blast radius, As well as dealing the standard 60 damage for a bomb, it will apply a Damage over Time effect that does 4 or 6 damage per tick, Has a chance to drop from the Super Sloth miniboss fight. Get hit by one enemy that does damage and you die. Unlockables can be gained through doing various tasks, such as destroying enough Poop, beating a chapter for the first time, or defeating a boss in a specific way. UNLOCK: Unlock this item by beating the Isaac boss with Azazel, * the satanic bible library pool, library room, book room pool, devil pool, devil room pool, devil deal, item room, treasure room, item room pool, the lost item pool, pentagram, star, grey, gray, red, When used, fires a 4 way brimstone laser in all cardinal directions, dealing a lot of damage to any enemies, Laser damage does not scale with your damage stat - its a fixed 10 damage per tick for 20 ticks (200 total per use), Has a chance to drop after you beat Krampus, If you get close enough to an enemy that has a large hitbox, you can hit it with 2 of the laser beams, allowing you to deal more damage, UNLOCK: Unlock this item by beating Krampus (Krampus is unlocked by taking 20 devil deal items), *, horns, grey, gray, white, red, dead, tongue, krampus head, When used, farts on nearby enemies and knocks them backwards away from Isaac, Allows you to reflect projectiles away from Isaac, REPENTANCE - Butter Bean now knocks back enemies and projectiles with significantly more force. Doors remain open when entering a room with enemies in it. When used, this card drops all of your hearts (including non-red hearts), coins, keys and bombs on the floor, This effect is done in the most efficient way possible - e.g. Each time you clear a room there is a chance a Red Room will spawn at one of the walls. Blood Bag) it will be rerolled into a random Item Room item, Cannot remove Azazel's Brimstone laser, or The Lost's Holy Mantle, REPENTANCE - Full run reroll effects are now able to remove heart containers and transformations if losing the respective items during the reroll, UNLOCK: Unlock this item by blowing up 30 slot machines, * item room, treasure room, item room pool, dice pip, starting, pyramid, green, triange, When used, 'devolves' all enemies in the room which are currently alive into another weaker type of enemy, * item room, treasure room, item room pool, DIO, dice pip, orange, brown, turban, When used, copies the effect of the card you are currently holding without consuming it, The charge time of this item depends on the quality of the card you're holding, Using this with the ? Can only happen once per room, Visually this is almost identical to the Guardian Angel item, but without a face, UNLOCK: Unlock this item by beating Blue Womb (Hush) with The Lost, A white orbiting fly which deals 3 contact damage per tick to enemies, This familiar orbits Isaac at a middle length distance somewhere between Distant Admiration and Forever Alone, Item Pool: Item Room, Greed Mode Item Room, Key Beggar. Ram damage formula has changed to damage * 4 + 28 (previously dealt a static 40 damage). At the full 12 charges Isaac does a massive shout, dealing 356 damage to all enemies on the screen, Larynx gains 1 charge every time you take damage (also charges as normal), UNLOCK: Unlock this item by defeating The Beast as Tainted Samson, Recharge time: 12 rooms (Can be used with partial charges), This item gives you a familiar version of The Lost character which dies instantly upon hit, If the familiar survives an entire floor you get one of: 3 soul hearts, 2 eternal hearts or a random item/angel room item, Regenerates at the start of each floor if dead, UNLOCK: Unlock this item by defeating Mother in the Corpse II as The Lost, Bombs now spawn a puddle of red creep upon explosion, dealing 2 damage per tick to enemies touching it, While at 0 bombs, you can also place further bombs now at the cost of 1/2 of a heart (kills The Lost if used like this). Plus this gambling machine is simple and quick, unlike the Slot Machines of old. pink, purple, Spawns a familiar leech on the ground that hunts down enemies and heals you for half a heart each time it eats one, The Leech deals 1.5 contact damage per tick, * item room, treasure room, item room pool, grey, gray, worm, A bag that follows Isaac and drops a random heart, coin, bomb or key every 5-6 rooms (alternating, 5 rooms then 6, then repeats), Can drop any kind of heart, coin, bomb or key, UNLOCK: Unlock this item by beating the Dark Room with Eden, Item Pool: Item Room, Beggar, Secret Room, * normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, secret room pool, item room, treasure room, item room pool, mysterious sack, multiple sacks, bag, pouch, purple, question mark, A large familiar black fly that bounces around the room, exploding on contact with enemies dealing 70 damage, Does not explode if it hits Isaac, however if it explodes on an enemy while Isaac is in range, he will take damage, Respawns after 10 seconds or by moving to another room, * item room, treasure room, item room pool, heart, smile, A green brain that launches in the direction you are firing your tears and will explode on contact with enemies, dealing damage and poisoning anything in the blast radius, Bob's Brain deals 100 damage and applies a poison damage over time effect, which deals double your tear damage per tick, Will hurt Isaac if he is in the blast radius. I agree with you on Spirit Sword, but I put it in the list because the difficulty to unlock it isn't that high for a tear replacer item that probably impacts your run positively in a major way. Damaging the aggressive Blood Puppy will eventually return it to its normal state. *, bag, grey, cry, blue, tear, shia paper bag sackhead, sad, Gives Isaac a cone of light infront of him that slows any enemies inside it and their tears, The light faces the direction that you are facing, not the direction you are firing, Removes Curse of Darkness for the current floor, if picked up on a floor where the curse is active, * Shop, Greed Mode Item Room, white, blue, inhaler, A purple familiar fly that follows your exact movement on a 1 second delay and deals 2 contact damage to enemies, When used, places an explosive TNT barrel next to you, The TNT barrel can be pushed and used to explode rocks or damage enemies, If used a second time in the same room while the last TNT barrel is still there, it will remotely explode the first TNT and not spawn another, REPENTANCE - Added to the Gold Chest Pool. Glitched Crown is in this list as the strongest among them once you learn how to pick out the item you want consistently. Following the path takes you to an abandoned mineshaft, which leads you to a pedestal with the Knife Piece. Items picked up are not shared between the two characters, UNLOCK: Unlock this item by defeating The Beast as Tainted Jacob, When activated, Isaac's tears are replaced by a bone sword and he goes on a killing rampage, gaining +0.4 Speed, +3 Flat Damage Up for 5 seconds, The sword deals x3 damage if used at close range, or x1.5 damage if charged up and thrown, Clearing rooms doesn't charge this item - charge is added equal to damage taken by enemies. Spawns another Vurp! What's new in Isaac repentance? blue, glow, arrow, cross, * astrology, astronomy, item room, treasure room, item room pool, cyan, black, blue, glow, n, tail, Leaves a trail of tears on the floor behind Isaac which damages enemies that walk over it for 2 damage per tick, REPENTANCE - Aquarius now synergizes with tear effects, * astrology, astronomy, item room, treasure room, item room pool, black, blue, cyan, blue, glow, Then, you must get a special key, which is composed of two pieces. * item room, treasure room, item room pool, money is power, dollar, red, grey, gray, Tears now have a random chance to freeze enemies in place, The chance to freeze enemies is affected by your luck stat, Chance to activate increases with luck, up to around 50% chance at +20 luck, UNLOCK: Unlock this item by collecting 3 'Mom' items in one playthrough, * item room, treasure room, item room pool, dungeon room, blood challenge room, arena pool, Tap the drop button to cycle between each one, Changes all card and rune drops into pills. paper, roll, white, All of Isaac's bombs now having a homing effect when placed on the floor, * boss rush pool, boss rush room, item room, treasure room, item room pool, bomb beggar, dead, Unlock Condition: Repentance added many new items into the Secret Room that basically instantly win you the run such as the Red Key, Rock Bottom ( ), and Echo Chamber ( ). 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