Download the YorkshireLive app to customise the news that matters to you and get the latest updates first. This is a promising alternative to conventional small molecule drugs which are often limited by poor penetration of the blood-brain barrier.. Office: 01-142-229-859, Copyright 2023 by the American Association for the Advancement of Science (AAAS), /Life sciences/Biochemistry/Biomolecules/, /Life sciences/Biochemistry/Biomolecules/Proteins/, /Life sciences/Biochemistry/Biomolecules/Proteins/Membrane proteins/, /Life sciences/Neuroscience/Cellular neuroscience/Neurons/, /Social sciences/Psychological science/Clinical psychology/Cognitive disorders/, Researchers from the University of Sheffields Institute of Translational Neuroscience have discovered how to prevent the death of nerve cells and protect nerves from neurodegeneration in the most common forms of MND and frontotemporal dementia, The researchers used a peptide, a small assembly of amino acids or protein bricks, with a cell-penetrating module to stop mutant repeated RNA molecules being transported from the cell's nucleus to the cytoplasm where they are used to produce toxic repeat proteins which lead to the death of nerve cells, Findings of the study suggest the peptide could be given orally in a non-invasive manner - for example through a nasal spray which could be developed to enter the brain, The groundbreaking concept of using peptides to block the nucleus-to-cytoplasm transport of the damaging repeat expanded RNA could transform how some neurodegenerative conditions, which currently have no cure, are treated. Enquiries are ongoing and he remains in police custody at this time. A post-mortem examination is due to take place in the coming days. FamilySearch. Read about our approach to external linking. Send your story ideas to yorkslincs.news@bbc.co.uk. Read about our approach to external linking. Database with images. It said Mohammed's death was not being treated as suspicious and his family was being supported by officers. The new study, conducted by researchers at the University of Sheffields Institute of Translational Neuroscience (SITraN), also showed that using a peptide to stop the transport of mutant repeated RNA molecules and production of toxic repeat proteins actually increases the survival of C9ORF72 nerve cells - protecting them against neurodegeneration. This work has provided important evidence in support of a completely new strategy to treat the most common inherited cause of both MND and FTD, with the ultimate goal of developing effective therapies for these devastating diseases.. The crash happened on December 9 at around 9pm and involved a black Toyota MR2 which was travelling along Hanover Way towards Moore Street roundabout. Promising MND drug helps slow disease progression and benefits patients physica. After an eight-day trial and three days of deliberations, the jury found her guilty on all counts, according to The News Herald, which included aggravated murder, murder and tampering with evidence on September 29, 2015. Join us on Facebook. Harry and Meghan told to 'vacate' Frogmore Cottage, Explosive found in check-in luggage at US airport, Fungus case forces Jack Daniels to halt construction, Rare Jurassic-era bug found at Arkansas Walmart, China and Belarus call for peace in Ukraine. The force has confirmed the death was a suicide. Mr Bennett added: "He's going to need a lot of help and our strength for him. WebSheffield-born man killed in USA car accident Doncaster-filmed Open All Hours actress Lynda Baron dies aged 82 Tributes pour in for popular footballer killed in crash Much The death is not being treated as suspicious.". The church opened this morning so that people could write in a book of condolences and light candles to remember the woman and three children who have been killed. In a statement, South Yorkshire Police said: "Shortly after 3am this morning (6 November), a man was discovered unconscious in Pond Street, Sheffield. A woman has died after being found "on fire" in a Sheffield park. This ground-breaking concept of using peptides to block the effects of the damaging repeat expanded RNA and toxic repeat proteins could transform how some neurodegenerative conditions which currently have no cure are treated. She said officers were particularly keen to speak to anyone who was in Chandos Crescent between 21:30 BST on Saturday and 07:30 BST on Sunday, and had any information that could help with their investigation. A man was found unconscious in Pond Street. Woodhouse murder: Suspected killers due in court over death of Sheffield woman Sarah Brierley Sheffield Star 11:38 28-Feb-23. "Each one of you is here to remember four people who are no longer with us," he said. This work has provided important evidence in support of a completely new strategy to treat the most common inherited cause of both MND and FTD, with the ultimate goal of developing effective therapies for these devastating diseases.. The BBC is not responsible for the content of external sites. "The commemoration lasted around 20 or so minutes with people of all ages, many standing in silence some with their arms round each other and visibly upset," she said. Media contact: For more information please contact: Amy Huxtable, Media and PR Officer, University of Sheffield, 07568116781, a.l.huxtable@sheffield.ac.uk, A cell-penetrant peptide blocking C9ORF72-repeat RNA nuclear export suppresses neurodegeneration. In a message posted on Facebook earlier, he said "life will never be the same". Terri was a beautiful and wonderful mother. South Yorkshire Police said the body was discovered at an address in Skelton Close, Woodhouse, just after 08:00 GMT. We use your sign-up to provide content in the ways you've consented to and improve our understanding of you. This study was made possible thanks to donated tissue samples from the skin of MND patients which were reprogrammed into nerve cells. As always you can unsubscribe at any time. This means that we may include adverts from us and third parties based on our knowledge of you. The 16 most up-and-coming areas in Sheffield according to census, including Devonshire Green and Park Hill News Take a look at our new and improved Chief Constable Rachel Swann described the deaths as a "shocking event". Senior investigating officer Andy Knowles said: "We are continuing our inquiries at pace to ensure that every piece of detail surrounding Sarah's death is obtained and investigated. On Jan. 1, Dominique Anderson, 28, was shot to death in an early-morning disturbance on Kerstetter Way. The British Library, London. Read about our approach to external linking. WebSheffield & South Yorkshire. South Yorkshire Police said: "Emergency services were called at around 3.45pm yesterday (Sunday, 25 April) following reports of concern for a woman in High Hazels Park, Sheffield. Blades ready to 'fight and scrap' for promotion. The crash happened on December 9 at around 9pm and involved a black Toyota MR2 which was travelling along Hanover Way towards Moore Street roundabout. Instead of using conventional drugs, which are inefficient in disrupting the stickiness of the SRSF1 protein, or invasive therapies to edit or modulate the activity of defective genes, the new study found that a small peptide incorporating a cell-penetrating module can stick to SRSF1 and effectively block the transportation of the rogue repeat RNA. "We have a large scene in place in the city centre while we carry out enquiries.. 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The BBC is not responsible for the content of external sites. The council will be renewing its nine Public Space Protection Orders until 2026. A man found unconscious in Sheffield city centre in the early hours of Saturday morning has tragically died in hospital. It's understood the Home Office was directly managing the now empty hotel at the time of the incident. Follow BBC East Midlands on Facebook, Twitter, or Instagram. Jenny Eells from BBC Radio Sheffield said people arrived to lay candles, flowers and teddies around a post in the centre of the children's playground. Sheffield City Council leader Terry Fox said: "This is absolutely devastating, just so incredibly sad. Hundreds of people from the Killamarsh community gathered at Baker Park near Chandos Crescent on Monday night for a vigil. TikTok Queen and my beautiful boy, they were beautiful.". The BBC is not responsible for the content of external sites. Organiser David Taylor, who is a local pastor from Church on the Street, said it was "a dark day in the place I call home". It is known as the Steel City because of its history of steel production. A woman has been found dead at a flat in Sheffield after officers forced entry to the property. The BBC is not responsible for the content of external sites. It also left three other people needing Mrs Bennett said Lacey was a West Ham fan and John Paul liked TikTok and computers. Jin Wang took over KH Oriental from his own father who founded Sheffields largest Chinese supermarket on London Road in 1976. 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Follow South Yorkshire Live or My Sheffield on Facebook and Twitter for the latest Sheffield news and follow Yorkshire Live on Instagram for beautiful images and stories. JB. South Yorkshire Polices serious collisions unit is now appealing for witnesses following the crash. WebThe Balance, 2 Pinfold Street. Attribution. A WOMAN is fighting for her life after a Mercedes smashed into a parked taxi. Scientists have found a novel way to block the transportation of mutant RNA and subsequent production of toxic repeat proteins which lead to the death of nerve cells in the most common subtypes of motor neurone disease (MND) and frontotemporal dementia (FTD). "It is vital the Home Office carry out an urgent investigation into what has happened so steps can be taken to quickly learn lessons. "Their dad was on holiday in Devon. It is reported Mohammed Munib Majeedi fell from a ninth-floor room where he was staying with his mother. A fellow Afghan staying in the hotel said Mohammed's family arrived in the UK 15 days ago. Follow BBC Yorkshire on Facebook, Twitter and Instagram. Or by navigating to the user icon in the top right. WebFind local and national death notices, funeral notices, obituaries, in memoriams, and acknowledgements at funeral-notices.co.uk, plus a directory of over 3,000 UK Funeral Police arrest man and woman for 'murder' as probe into death of Sarah Brierley at Sheffield home continues . The city is also home to Sheffield Arena, a popular venue, and the large shopping centre Meadowhall. Records extracted by FindMyPast and images digitized by FamilySearch. There is no cure for FTD, and no treatments available to slow or stop the progression of the disease. The council will be renewing its nine Public Space Protection Orders until 2026. David Scott, 39, and Zoe Clarke, 38, both of Woodhouse, Sheffield, have been charged with the 49-year-old's murder and remanded in custody, South Yorkshire Enver Solomon, chief executive of the Refugee Council, said: "This a terrible tragedy and our thoughts are with the family who have gone through so much trauma and suffering to reach the UK. WebCite This Collection. Killamarsh is a community in mourning and disbelief, according to the Rev Canon Helen Guest, rector at St Giles Church. Sheffield, Yorkshire. 1937 - 2021, aged 84. Amy Pullan Read about our approach to external linking. "Sadly, the woman was pronounced dead at the scene. 2023 BBC. Send your story ideas to yorkslincs.news@bbc.co.uk. The Outwood Academy City school in Sheffield confirmed it was closed following the "tragic incident" involving three of its students. 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Two suspected murderers are due to appear at Sheffield Crown Court today, Tuesday, February 28, after the death of Sarah Brierley at a property in the citys Woodhouse neighbourhood. WebFollow the latest news for Sheffield in South Yorkshire, England, UK - Local news and information in your area Latest News in Sheffield in South Yorkshire, England, UK - Following the vigil he told the BBC: "Many of them wanted to be able to come and show their feelings for one another, for the community and to be there to support one another. Send your story ideas to yorkslincs.news@bbc.co.uk. "They are so upset, they are so unhappy," he said. News you can trust since 1887. Dr Brian Dickie, Director of Research at the MND Association, said: These findings from a world leading research team in Sheffield demonstrate the importance of funding fundamental discovery science. MND is a debilitating condition that destroys the cells that control movement, leaving sufferers unable to move, walk, talk and eventually breathe. Posted. "It's such a close knit community I think it has affected everybody. A man has tragically died after his car came off the road in a horror crash in Sheffield's city centre. 4d. News. 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Read about our approach to external linking. FTD occurs when nerve cells in the frontal and temporal lobes of the brain are lost, causing the lobes to shrink. South Yorkshire Police have confirmed that emergency services were called to High The third child has been named as Connie Gent, 11, from Sheffield. South Yorkshire Police said the body was discovered at an address in Webnews, sport, business, politics and more, from Sheffield's newspaper, The Star. This concept of using peptides to block destructive mutations unlocks such an exciting and innovative treatment pathway which until now has not been explored by scientists. "The area was cordoned off while enquiries were conducted. The road was closed from 9pm on December 9, The latest Sheffield news and updates delivered to your inbox. Mrs Bennett said: "They were beautiful, well mannered kids. "A tragic incident has taken place in the community involving 3 of our students. Read about our approach to external linking. 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